Our research group studies the mechanisms of protein trafficking and quality control at the endoplasmic reticulum (ER) in mammalian cells. A major focus of research is on the COPII protein machinery ...

How is plasma membrane protein composition controlled? There are several control mechanisms, most of which depend on endosomal trafficking pathways. Plasma membrane proteins reach the endosomes by ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Figure 1. Entosis promotes cell competition. (A) Entosis ...

Additionally, the ORF3a-VPS39 interaction reduces BMP levels by an undefined mechanism ... and host protein VPS39, the study highlights a critical role of lysosomal cholesterol trafficking ...

The study focuses on a short, 10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking ... into the complex mechanisms underlying protein glycosylation." ...