and antigen presentation. Macrophages tailor their response to their local microenvironment. In the cutaneous setting, macrophages participate in the immune response to diverse stimuli such as ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in ...

Macrophages are intricately involved in the presentation of antigens to lymphocytes and in the subsequent removal of immune complexes. Therefore, pharmacologic manipulation of these cells may ...

Additionally, the CAR-M produced pro-inflammatory cytokines and adopted an inflammatory, activated macrophage phenotype upon antigen engagement. In both syngeneic and humanized tumor models ...

More information: Kun Chen et al, CAR-macrophage versus CAR-T for Solid Tumors: The Race between A Rising Star and A Superstar, Biomolecules and Biomedicine (2023). DOI: 10.17305/bb.2023.9675 ...

PHILADELPHIA, PA — Carisma Therapeutics Inc. (Nasdaq: CARM) is set to present significant advancements ... of a novel ...