Interest in lysosomal storage diseases (LSDs ... Gaucher's disease is caused by a deficiency of glucocerebrosidase (GCR) and was the first disease in which enzyme-replacement therapy became ...

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Even more fascinating is the intricate relationship between lysosomal exocytosis ...

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates ... Xiong, W., and Zheng, H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology ...