The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

Ubiquitylation requires the subsequent actions of three enzymes: an activating E1, a conjugating E2 and an E3 ligase. Hoeller et al. now show that monoubiquitylation of ubiquitin-binding domain ...

The gap-ligation reaction is considered preferable for allele ... The third assay method, the ligase-mediated extension of an oligonucleotide linked to a solid surface, provides a novel approach ...