The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Because DNA replication errors or environmental agents ... scaffold proteins Rtt107 and Mms22 and their associated ubiquitin ligase enable this downregulation and reduces the level of a key ...

the helix structure is unwound special molecules break the weak hydrogen bonds between bases, which are holding the two strands together this process occurs at several locations on a DNA molecule ...

Direct sequencing-based assays have limited sensitivity, while assays based on PCR restriction fragment-length polymorphisms (RFLPs), pyrosequencing, PCR–ligase detection reaction, mutant ...