The user would need to ingest DNA from the previous wielder of One For All. This is how the lead character, Izuku Midoriya, also known as Deku, gained superpowers despite growing up without a quirk.

Deku's ultimate fate was unexpected for many fans, but there's an early piece of information that hinted at what would become of the young hero.

But to reach Shigaraki, Izuku will need to keep All For One off his back, and take the villain out of the equation: so why not let Bakguo (All Might’s other protege) be the one who does it?

This Quirk gives All Might exceptional strength, speed, endurance, and agility, making him the number one hero in his prime.