Mast cells are the primary effector cell of urticaria. They are widely distributed in the skin, intestinal mucosa, alveolar wall, and nasal mucosa, and have high-affinity IgE receptors (FcRI).

A team of researchers from Carnegie Mellon University's Department of Biological Sciences and the University of Texas ...

Reduced number of T cells has been correlated with intestinal epithelial injury after ... which then crosslinks preformed drug-specific IgE on mast cells, activating a cascade for allergic reaction.

A new approach to treat rosacea and other inflammatory skin conditions could be on the horizon, according to a University of ...

TRPV1 levels—previously associated with intestinal disorders including ... as were c-kit-expressing mast cells and CD3 + T cells (both of which are markers of inflammation).