In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway.

In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

suggesting that insulin resistance occurred despite normal insulin signaling pathways. HFD-fed wild-type mice had elevated ...

Dopamine receptors bind dopamine, insulin receptors bind insulin ... through a sequence of molecular switches to internal signaling pathways. Membrane receptors fall into three major classes ...

Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface ...

Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving insulin sensitivity. Brief Communication: Expression of p53 in human ...

By leveraging insights and tools, healthcare professionals can better address the intertwined challenges of obesity and T2D, ...

Insulin resistance refers to impaired insulin ... This not only adds to our understanding of biology and signaling pathways in cells, but, more importantly, it is leading to exciting new ...

This can disrupt insulin signaling pathways, a sign of insulin resistance. • Poor diet: Consuming a poor-quality diet high in processed foods, refined carbohydrates, and sugary beverages ...

Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface ...