Investigational models like the histamine-induced skin wheal-and-flare ... indicator of the effectiveness of an H 1-receptor antagonist in clinical practice. For the antihistamine desloratadine ...

Vogt produce histamine synthetically by removing the ... 1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999—Researchers at a subsidiary of Johnson ...

This overzealous response is triggered by one of the most basic biological messengers, histamine, which has cell receptors in nearly every organ. Allergy medications on the market target these ...

Famotidine is a competitive inhibitor of histamine-2 (H2) receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric secretion. Both the acid ...

Abstract and Introduction Predicting and Establishing the Clinical Efficacy of a Histamine H Application ... mechanisms of action of H 1-receptor antagonists and to predict their clinical efficacy.