are due to its lower affinity for heparin-binding proteins and endothelial cells, shorter fractionated heparin chain (which allows for better bioavailability), and unsaturable renal elimination.

The dependence of their activity on heparin binding has been a puzzle that, in recent years, has been the subject of active investigation. Recent structural analyses on complexes of FGFs with ...

In light of the increasing amount of genetic information that is becoming available through sequencing efforts, it is now apparent that high-throughput systems that can provide a global view of ...

Based on neurite outgrowth assays, we have previously isolated, cloned, and produced as recombinant proteins two ligands of heparan sulfate proteoglycans (HSPGs), HMGB1 (high-mobility group B1; ...