The atomic structure of hemoglobin, determined by Max Perutz ... Today, despite the detailed molecular explanation of the cause, sickle cell anemia is still a serious clinical problem.

In sickle cell disease, a gene mutation causes the hemoglobin molecules ... protein wrapped around a zinc molecule. Orkin's team has now reported the crystal structure of the BCL11A tetramer ...

It was not clear why a relatively innocuous heme molecule should be ... displace O 2 from myoglobin and hemoglobin. Several interesting results emerge from the structure of HO-1.