Although absolute glycosuria decreases with declining GFR, the efficiency of ipragliflozin action (fractional glucose excretion) is maintained in patients with severe renal impairment. Patients ...

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In two large randomized controlled trials of patients with Type 2 diabetes, fenofibrate was shown to be able to reduce albuminuria and slow the rate of calculated glomerular filtration rate (GFR ...

These factors include diabetes, proteinuria and markers of inflammation ... combination to minimize the confounding effects of non-GFR determinants.