A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

A study at MedUni Vienna's Department of Dermatology provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory ...

More information: Agnes Forsthuber et al, Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy, Nature Communications (2024).

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Through a comprehensive study of fibroblasts in the tumor environment, including their interaction with other cells such as epithelial, mesenchymal and immune cells, three clearly distinguishable ...

“Interestingly, it was shown that healthy fibroblasts that are exposed to the secretome of skin cancer cells in the laboratory develop a similar behavior to iCAFs and are capable of activating ...