Fatty acid synthase, the enzyme responsible for fatty acid production in cells, may be a therapeutic target for IPF, a mouse ...

Increased matrix production is the most direct way that stellate cell activation generates hepatic fibrosis. The most potent stimulus to collagen ... and fibroblast activation protein; [38 ...

The process by which lung injury either leads to healing or fibrosis relies in part on what happens to a cell called a ...

Scleroderma is an autoimmune connective-tissue disease whose hallmark is excessive collagen deposited around capillaries and in affected tissues, such as the skin, lungs, kidneys, and esophagus.

The progressive build-up of activated fibroblasts and collagen deposition in ... goal of treating heart failure. As fibrosis is also involved in the lung and in the microenvironments of some ...

The study was recently published in Science Translational Medicine and showed how dextromethorphan can impede the collagen that forms scars inside cells, reducing lung fibrosis. Lung fibrosis—caused ...

Discover the latest advancements in lung ... and Fibroblast Models. This resource provides insight into how these models are helping researchers understand chronic lung diseases, tackle fibrosis ...

Specifically, the mechano-regulation of inflammation, extracellular matrix and fibroblast functional phenotype that results in a spectrum of tissue fibrosis outcomes. We utilize basic science and ...