Fibroblasts are specialized cells in connective tissues that play an important role in wound healing and tissue repair. They produce and organize the so-called extracellular matrix, a network of ...

Quantitative and qualitative changes in matrix protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix Degradation ...

My lab is interested in understanding how the structure of the three-dimensional (3D) extracellular matrix dictates the molecular and physical mechanisms driving cell motility. For example, we ...

The brain extracellular matrix plays a critical role in synaptic plasticity, including experience/adaptive-based changes in ...

One such cell type, cancer-associated fibroblasts, affects tumor progression in multiple ways, including modifying the stiffness and composition of the extracellular matrix, promoting and ...

Human lung fibroblasts stimulated with TGF-β1 to detect extracellular collagen I (pink), alpha-smooth muscle actin (α-SMA) (green), and cell nuclei (blue) as a measure of matrix production and ...