To test how RANK–RANKL signalling directly affects intestinal epithelial cells, we exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine-resident stem ...

In vivo, the intestinal ... include humanized stem cell-derived in vitro systems that recreate the epithelial cell layer makeup and morphology. 2 Towards this end, scientists increasingly employ ...

Researchers currently use extracts from the basement membrane, a specific type of extracellular matrix, to culture organoids ... term from human intestinal and airway cells, mouse intestinal ...

We strive to understand the molecular and cellular regulation of epithelial appendage (hair ... we use a combination of genetic mouse models, single cell and bulk transcriptomics, organ and cell ...

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially ...

All cell culture reagents were obtained from Invitrogen (Carlsbad, CA). Temperature sensitive fetal human intestinal epithelial cells (tsFHI) cell lines were a kind gift from Dr. Andrea Quaroni.