On the other hand, PP1 and calcineurin activation conversely increased sleep duration and delta power. In these sleep–wake promoting activities, it is essential that PKA, PP1, and calcineurin ...

We previously reported sustained calcineurin (Cn) activation in human lymphoid malignancies, and showed that Cn inhibitors have antileukemic effects in mouse models of T-ALL. It was unclear ...

You have full access to this article via your institution. Though activation of the calcineurin pathway can produce cardiac hypertrophy in transgenic mice 3, the results of our study indicate that ...

A person may be able to treat eczema without steroids. Possible treatment options include topical calcineurin inhibitors, crisaborole, JAK inhibitors, and more. Corticosteroids (steroids ...