The Scientist11mon
Infographic: The Cre-lox System Explained
To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...
Nature5y
Floxed Targeted Mouse Strain with Conditional Deletion of the Irf8 Gene: Collaborative and Licensing Opportunity
The Irf8 floxed mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the identification of IRF8 ...
EurekAlert!2y
c-kit IRES-Cre Mice Allow for Molecular Layer Interneurons Targeting in Mature Mice (IMAGE)
The cerebella from c-kit IRES-Cre mice injected with Cre-reporter virus at PND (pups shortly after birth) 0 or PND 64. Tissue was prepared from animals 27 and 14 days after injection ...
gut.bmj2mon
STK33 promotes hepatocellular carcinoma through binding to c-Myc
Using a TAM-inducible, hepatocyte-specific STK33 knockout mouse model, we found that, when subjected to the diethylnitrosamine (DEN) liver cancer bioassay, STK33KO flox/flox, Alb-ERT2-Cre mice ...
eLife29d
NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
In this study we show that NR2F2 is expressed in interstitial progenitors of coelomic and mesonephric origin of the mouse fetal testes and is downregulated upon FLC differentiation. By using two Cre ...