The current recommendation is that other medications be taken at least 1 hour before or 4 to 6 hours after the bile acid-binding resin. This may limit the use of resins in patients taking multiple ...

DRUG INTERACTIONSFor patients taking bile acid binding resins, take BYLVAY at least 4 hours before or 4 hours after administering, as bile acid binding resins may bind to and reduce BYLVAY efficacy.

Interestingly, the substitution of Glycine by Arginine in mNTCP was at a position far away from the binding site for bile acid. Prof. Watashi adds, “These animals probably evolved to acquire ...

In both human muscle cells and mouse brown adipocytes, bile acids increased D2 activity and oxygen consumption by binding to the G-protein-coupled receptor TGR5, causing cyclic AMP levels to rise.

Bile acid sequestrants are nonsoluble polymers that trap bile acids in the intestinal lumen and promote their excretion in feces. As a consequence, they lower the hepatic cholesterol pool and ...