Dr. Timothy Palzkill, professor of Pharmacology and Chemical Biology and Molecular Virology and Microbiology, and his research team have been studying mechanisms of resistance to the beta-lactam ...

Both approaches require understanding of the structure and mechanism of resistance enzymes ... the most potent beta-lactam antibiotics, and the mobile colistin resistance determinant MCR-1. The team ...

In a new study published on September 27 in Nature Communications, researchers from Duke University have discovered the mechanism ... bacteria become resistant to beta-lactam by creating an ...

The bacterial envelope offers the first line of defence against antimicrobials. Understanding how bacteria control the entry and efflux of chemicals helps us to explain and possibly reverse ...

BLIs are designed to overcome a key resistance mechanism that allows pathogens to protect themselves from cefepime and other antibiotics in the beta-lactam class and have been used to restore acti ...

Beta-lactamase inhibitors are designed to overcome a key resistance mechanism that allows pathogens ... which combines xeruborbactam with an oral beta-lactam QPX2015 and is in phase 1b testing ...

A particular focus has been on β-lactamases, which hydrolyze β-lactam antibiotics ... leading to resistance. We determined the first X-ray structure of the catalytic domain and are working on the ...