Two decades ago, a link between apoptosis and cancer was recognized, following the discovery that the protein BCL-2 specifically blocked apoptotic death of B cells in follicular lymphoma.

BCL-2 inhibitors, such as venetoclax (Venclexta) work by targeting the BCL-2 protein, which plays a key role in preventing ...

Multiple myeloma cells carry a protein called BCL-2 that keeps the cell from triggering apoptosis. Venclexta inhibits BCL-2, restoring natural cell death for these cancer cells. The U.S. Food and Drug ...

Venclexta keeps cancer cells from dodging apoptosis, the body process that causes old or damaged cells to self-destruct. Multiple myeloma cells carry a protein called BCL-2 that keeps the cell ...