The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

While hallmark features like tau tangles and amyloid beta (Aβ) plaques are well-known ... Another important finding involves the APOE gene, already well known for its role in the disease.

ApoE additionally enables the transport of extracellular Aβ across the BBB. Aβ: Amyloid-β; ABC: ATP-binding cassette; BBB: Blood–brain barrier; LDLR: LDL receptor; LXR: Liver X receptor.

Molecular Neurodegeneration. This advanced course covers several of the most important molecules involved in neurodegenerative disease, including Aβ, tau, apoE, TDP-43, α-synuclein, LRRK2, prion ...