Columbia is a city in Missouri, United States. It was founded in 1821 as the county seat of Boone County and had a population of 126,254 record…Columbia is a city in Missouri, United States. It was founded in 1821 as the county seat of Boone County and had a population of 126,254 recorded in the 2020 census, making it the fourth-most populous city in Missouri. Columbia is a Midwestern college town, home to the land-grant University of Missouri, a major research institution with over 30,000 students. Surrounding Downtown Columbia are also Stephens College and Columbia College giving the city its educational focus. It is the principal city of the Columbia metropolitan area, population 215,811, and the central city of the nine-county Columbia–Jefferson City–Moberly combined statistical area with 415,747 residents.