De Witt is a city in Carroll County, Missouri, United States. The population was 83 at the 2020 census. A post office called De Witt has been in o…De Witt is a city in Carroll County, Missouri, United States. The population was 83 at the 2020 census. A post office called De Witt has been in operation since 1842. The community was named for DeWitt Clinton, governor of New York.