Topsham is a town in Devon, England, located on the east side of the River Exe, immediately north of its confluence with the River Clyst and the former's estuary, between Exeter and Exmouth. Topsham is a historic port and was designated a town by a 1300 royal charter granted by Edward I; it was formally amalgamated into the City of Exeter in 1966. The population of the town, recorded at the 2021 census, is 4,146.