Saint Charles is a city in, and the county seat of, St. Charles County, Missouri, United States. The population was 70,493 at the 2020 cens…Saint Charles is a city in, and the county seat of, St. Charles County, Missouri, United States. The population was 70,493 at the 2020 census, making St. Charles the ninth-most populous city in Missouri. Situated on the Missouri River, St. Charles is a northwestern suburb of St. Louis.
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