Pine Island is the largest island on the Gulf Coast of peninsular Florida in the United States. Located in Lee County, on the Gulf of Mexico coast of southwest Florida, it is also the 118th largest island in the United States. The Intracoastal Waterway passes through Pine Island Sound, to the west of the island. Matlacha Pass runs between Pine Island and the mainl…Pine Island is the largest island on the Gulf Coast of peninsular Florida in the United States. Located in Lee County, on the Gulf of Mexico coast of southwest Florida, it is also the 118th largest island in the United States. The Intracoastal Waterway passes through Pine Island Sound, to the west of the island. Matlacha Pass runs between Pine Island and the mainland. Pine Island lies west of Cape Coral. For many years, Pine Island was a major commercial fishing community and many of its full-time residents still fish commercially today.
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