Middleport is the largest village in Meigs County, Ohio, along the Ohio River. The population was 2,208 at the time of the 2020 census. Middleport was founded during the 1820s, a time of great prosperity and rapidly increasing commerce in Meigs County. Among its earliest industries was a cotton mill, built despite the lack of cotton production in the vicinity. The village was founded as "Sheffield", and throughout its history it has also used the names of "Coalport" and "Salisbury". The name Middleport refers to the city's location on the Ohio River halfway between Pittsburgh and Cincinnati. Three Middleport buildings, the John Downing Jr. House, the William H. Grant House, and the Middleport Public Library, are listed on the National Register of Historic Places.
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