Galena is a city in the Yukon-Koyukuk Census Area in the U.S. state of Alaska. At the 2020 census the population was 472, slightly up from …Galena is a city in the Yukon-Koyukuk Census Area in the U.S. state of Alaska. At the 2020 census the population was 472, slightly up from 470 in 2010. Galena was established in 1918, and a military airfield was built adjacent to the city during World War II. The city was incorporated in 1971.