The Eno River, named for the Eno Native Americans who once lived along its banks, is the initial tributary of the Neuse River in North Carolina, United States. Descendants of European immigrants settled along the Eno River in the latter 1740s and early 1750s, including many Quakers from Pennsylvania. Several years after the 1752 creation of Orange Count…The Eno River, named for the Eno Native Americans who once lived along its banks, is the initial tributary of the Neuse River in North Carolina, United States. Descendants of European immigrants settled along the Eno River in the latter 1740s and early 1750s, including many Quakers from Pennsylvania. Several years after the 1752 creation of Orange County, the Orange County Court of Common Pleas & Quarter Sessions selected a site along the Eno River near the homes of James Watson and William Reed as the county seat, originally naming it Corbin Town, or Corbinton, after Francis Corbin, agent and attorney to John, Earl Granville. The Court met at James Watson's home along the Eno River from 1754 through 1756, when the courthouse at Corbinton was completed. In 1759, officials changed the county seat's name from Corbinton to Childsburg, after another of Earl Granville's agents, Thomas Child. Finally, in 1766, officials changed the name to Hillsborough.